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Aliskiren suppresses the compensatoryincrease in plasma renin (so called “hyperreninemia”) andcauses additional blood pressure lowering when combinedwith a thiazide diuretic, an ACEI or ARBs.79 When aliskiren iscombined with valsartan at maximum recommended doses, itprovides significantly greater reduction in blood pressure thanmonotherapy with either agent alone. These p63REs exhibit characteristic differences from thecanonical p53RE (RRRCWWGYYY) in both the core-binding element (CWWG)as well as the RRR and/or YYY sequences [ 28].

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